Name | 4-Aminoquinaldine |
Synonyms | AKOS AUF2104 4-Aminoquinaldine 4-AMINOQUINALDINE TIMTEC-BB SBB003992 LABOTEST-BB LT02084860 2-Methyl-4-quinolinamine 2-methylquinolin-4-amine 4-AMINO-2-METHYLQUINOLINE 4-Amino-2-methylquinoline 2-METHYLQUINOLIN-4-YLAMINE 4-Quinolinamine, 2-methyl- 4-amino-2-methylquinolinium |
CAS | 6628-04-2 |
EINECS | 229-604-4 |
InChI | InChI=1/C10H10N2/c1-7-6-9(11)8-4-2-3-5-10(8)12-7/h2-6H,1H3,(H2,11,12)/p+1 |
InChIKey | COCFIBRMFPWUDW-UHFFFAOYSA-N |
Molecular Formula | C10H10N2 |
Molar Mass | 158.2 |
Density | 1.1606 (estimate) |
Melting Point | 162-166°C(lit.) |
Boling Point | 333°C(lit.) |
Flash Point | 333°C |
Water Solubility | Soluble in water. |
Solubility | soluble in Methanol |
Vapor Presure | 0.001Pa at 25℃ |
Appearance | powder to crystal |
Color | White to Orange to Green |
BRN | 118323 |
pKa | 9.40±0.50(Predicted) |
Storage Condition | Room Temprature |
Refractive Index | 1.7080 (estimate) |
MDL | MFCD00006759 |
Physical and Chemical Properties | Crystals. Melting point of 169-170 ° C, boiling point of 333 ° C, soluble in benzene, ether and ethanol. |
Use | Used as a pharmaceutical intermediate. |
Hazard Symbols | Xi - Irritant |
Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
UN IDs | 3259 |
WGK Germany | 3 |
HS Code | 29334900 |
Hazard Class | 8 |
Packing Group | III |
LogP | 1.77 |
Use | is useful as a pharmaceutical intermediate. |
production method | is obtained by amination of 4-chloroquinaldine. 4-chloroquinaldine and benzene were mixed, and the mixture was refluxed and dehydrated until no water was taken out, and evaporated to dryness under reduced pressure. The temperature was gradually increased to 160 ° C. By the addition of phenol and the ammonia was permeated while heating, and a low boiling material was recovered. Continue ammonia at 160-180 ℃ for 2H, then cool to room temperature and add benzene, filter, filter cake is washed with benzene, heat water solution to remove oil layer, water layer is decolorized with activated carbon, filter, the filtrate was made highly alkaline with sodium hydroxide solution to precipitate a white or yellowish solid to give 4-aminoquinaldine. The melting point is about 160 °c. |